![]() These are meant for oral or external application to mucous membranes and can be ingested without water. Or suspensions made up of small inorganic particles or large organic molecules interpenetrated by a liquid. Katakam Prakash, Department of Pharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, University of Zawia, Az Zawiyah, Libya. Jellies are transparent or translucent nongreasy semisolid solutionsĭr. Oral jellies as unit dosage forms can offer a better solution to address these problems. Pediatrics patient compliance with convenient administration and more palatable and elegant dosage forms are gaining significant importance in the design of novel drug delivery systems.11 Therefore, there is a scope for more patient-friendly delivery systems which involve easy administrative methods, especially by oral route. Reconstitution, dose dumping, ease of administration, patient nonacceptance and so on. Although the spectrum of dosage forms available to these patients such as syrups, suspensions, chewable tablets, dispersible tablets and powders for reconstitution many questions and expectations are still to be addressed such as stability, dosage wastage, improper measurement, Patient compliant dosage forms show beneficial over conventional ones, especially if the drug delivery problems of pediatric, geriatric and dysphagic patients are addressed. ![]() Key words: Carbamazepine, dysphagic patients, medicated jelly, natural polymersĭevelopment of novel drug delivery techniques that minimize toxicity and improve efficacy offers prospective benefits to patients and opens new avenues for pharmaceutical companies. The jellies could be useful to overcome the problems of poorly soluble CBZ. Carbamazepine jellies made from pectin (F3, 1.2%), gellan gum (F11, 1.5%) and pectin-guar gum (F15, 1:0.4%) were found more successful and could be employed to improve the palatability and acceptability by pediatric, geriatric and dysphagic patients. The formulations F3, F11 and F15, were found stable for 90 days as per International Conference on Harmonization stability protocol. All formulations showed more than 50% drug release in 15 min except those made of gellan gum alone. The optimized formulations (F3, F11 and F15) masked the bitter taste of CBZ and demonstrated acceptable flavor and mouth feel. Syneresis was observed in jellies made from guar gum alone, whereas those made from pectin and guar gum it was absent. The concentration of gelling agents influenced the spreadability. The pH of all the formulations was found between pH 6.37 ± 0.03 and 6.83 ± 0.04. ![]() The Fourier transform infrared and differential scanning calorimeter studies showed that there was no interaction between drug and excipients. Preformulation studies, organoleptic, physical characteristics, drug content, pH, spreadability, rheological properties, syneresis, taste masking, in vitro dissolution testing, drug release kinetics and stability studies were conducted. Carbamazepine oral jellies were prepared to employ pectin, guar gum and gellan gum alone and pectin-guar gum combination. The aim was to develop and evaluate oral jelly formulations of carbamazepine (CBZ). Medicated jelly formulations are more suitable for pediatric, geriatric and dysphagic patients, which offer rapid dissolution and absorption of drugs thereby early onset of action. ![]() Prameela2ġDepartment of Pharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, University of Zawia, Az Zawiyah, Libya, department of Pharmaceutics, College of Pharmaceutical Sciences, Acharya Nagarjuna University, 3Department of Pharmaceutics, Nirmala College of Pharmacy, Mangalagiri, Guntur, Andhra Pradesh, India Formulation development and evaluation of novel oral jellies of carbamazepine using pectin, guar gum, and gellan gum
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